Os30
Product Specifications
UNSPSC Description
Os30, a potent fourth-generation EGFR inhibitor, is a potent EGFRC797S-TK inhibitor with IC50 values of 18 nM and 113 nM for EGFRDel19/T790M/C797S TK and EGFRL858R/T790M/C797S TK, respectively. Os30 can suppress EGFR phosphorylation, arrest at G1 phase and induce the apoptosis of KC-0116 (BaF3-EGFRDel19/T790M/C797S) cells. Os30 shows potent antitumor efficacy on non-small cell lung cancer (NSCLC) with EGFmRC797S mutation[1].
Target Antigen
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/os30.html
Solubility
DMSO : 50 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
CN(C1=C2C=CC=C1)C=C2C3=CC=NC(NC4=CC(NS(C)(=O)=O)=C(N5CCC(N(C)C)CC5)C=C4)=N3
Molecular Weight
519.66
References & Citations
[1]Xiao-Xiao Xi, et al. Modification of osimertinib to discover new potent EGFRC797S-TK inhibitors. Eur J Med Chem. 2023 Dec 5:261:115865.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-155358/Os30-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-155358/Os30-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2998928-68-8
Available Sizes
Curated Selection
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