Os30

Os30, a potent fourth-generation EGFR inhibitor, is a potent EGFRC797S-TK inhibitor with IC50 values of 18 nM and 113 nM for EGFRDel19/T790M/C797S TK and EGFRL858R/T790M/C797S TK, respectively. Os30 can suppress EGFR phosphorylation, arrest at G1 phase and induce the apoptosis of KC-0116 (BaF3-EGFRDel19/T790M/C797S) cells. Os30 shows potent antitumor efficacy on non-small cell lung cancer (NSCLC) with EGFmRC797S mutation[1].

Product Specifications

CAS Number

[2998928-68-8]

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/os30.html

Purity

98.34

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

CN(C1=C2C=CC=C1)C=C2C3=CC=NC(NC4=CC(NS(C)(=O)=O)=C(N5CCC(N(C)C)CC5)C=C4)=N3

Molecular Formula

C27H33N7O2S

Molecular Weight

519.66

References & Citations

[1]Xiao-Xiao Xi, et al. Modification of osimertinib to discover new potent EGFRC797S-TK inhibitors. Eur J Med Chem. 2023 Dec 5:261:115865.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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