D-Serine

D-Serine ((R) -Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].

Product Specifications

CAS Number

[312-84-5]

Product Name Alternative

(R) -Serine

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; iGluR

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/_R_-Serine.html

Purity

98.0

Solubility

H2O : ≥ 50 mg/mL|Methanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N[C@H](CO)C(O)=O

Molecular Formula

C3H7NO3

Molecular Weight

105.09

Precautions

H302, H315, H319, H335

References & Citations

[1]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.|[2]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25.|[3]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10 (1) :1986.|[4]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.