D-Serine
Product Specifications
UNSPSC Description
D-Serine ((R)-Serine), an endogenous amino acid involved in glia-synapse interactions that has unique neurotransmitter characteristics, is a potent co-agonist at the NMDA glutamate receptor. D-Serinee has a cardinal modulatory role in major NMDAR-dependent processes including NMDAR-mediated neurotransmission, neurotoxicity, synaptic plasticity, and cell migration[1][2].
Target Antigen
Endogenous Metabolite; iGluR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_R_-Serine.html
Purity
98.0
Solubility
H2O : ≥ 50 mg/mL|Methanol : < 1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
N[C@H](CO)C(O)=O
Molecular Weight
105.093
References & Citations
[1]Andrea R. Durrant, et al. D-Serine in Neuropsychiatric Disorders: New Advances.|[2]MacKay MB, et al. D-Serine: Potential Therapeutic Agent and/or Biomarker in Schizophrenia and Depression? Front Psychiatry. 2019 Feb 6;10:25.|[3]Dai X, et al. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.|[4]Suwandhi L, et al. Chronic d-serine supplementation impairs insulin secretion. Mol Metab. 2018 Oct;16:191-202.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-100808/D-Serine-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-100808/D-Serine-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
312-84-5
Available Sizes
Curated Selection
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