MK-7622
MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs). MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine -induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD)[2].
Product Specifications
CAS Number
1227923-29-6
Product Name Alternative
M1 receptor modulator
UNSPSC
12352005
Target
Calcium Channel; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/M1-receptor-modulator.html
Purity
99.89
Solubility
DMSO : 70 mg/mL (ultrasonic)
Smiles
O=C1N([C@@H]2[C@@H](O)CCCC2)C=NC3=C1C=C(CC4=CC=C(C)N=C4)C5=CC=CC=C53
Molecular Formula
C25H25N3O2
Molecular Weight
399.48
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MAChR1
Available Sizes
Frequently Asked Questions
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