MK-7622

MK-7622 (M1 receptor modulator) is an orally active positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs) . MK-7622 enhances ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM) and shows robust agonist activity in rat M1-expressing CHO cells, increasing intracellular calcium. MK-7622 reverses Scopolamine (HY-N0296) -induced cognitive deficits in rhesus macaques in an object retrieval detour task. MK-7622 can be used for the study of Alzheimer's disease (AD) [1][2].

Product Specifications

CAS Number

[1227923-29-6]

Product Name Alternative

M1 receptor modulator

UNSPSC

12352005

Target

Calcium Channel; mAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/M1-receptor-modulator.html

Purity

99.89

Solubility

DMSO : 70 mg/mL (ultrasonic)

Smiles

O=C1N([C@@H]2[C@@H](O)CCCC2)C=NC3=C1C=C(CC4=CC=C(C)N=C4)C5=CC=CC=C53

Molecular Formula

C25H25N3O2

Molecular Weight

399.48

References & Citations

[1]Uslaner JM, et al. Preclinical to Human Translational Pharmacology of the Novel M1 Positive Allosteric Modulator MK-7622. J Pharmacol Exp Ther. 2018 Jun;365 (3) :556-566. |[2]Moran SP, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43 (8) :1763-1771. |[3]Beshore DC, et al. MK-7622: A First-in-Class M1Positive Allosteric Modulator Development Candidate. ACS Med Chem Lett. 2018 Apr 30;9 (7) :652-656.