Arginase inhibitor 1

Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.

Product Specifications

CAS Number

[1345808-25-4]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Arginase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Arginase-inhibitor-1.html

Purity

98.0

Solubility

DMSO : ≥ 48 mg/mL|H2O : ≥ 30 mg/mL

Smiles

O=C(O)[C@@](CCN1CCCCC1)(N)CCCCB(O)O

Molecular Formula

C13H27BN2O4

Molecular Weight

286.18

Precautions

H302, H315, H319, H335

References & Citations

[1]Van Zandt MC, et al. Discovery of (R) -2-amino-6-borono-2- (2- (piperidin-1-yl) ethyl) hexanoic acid and congeners as highly potentinhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56 (6) :2568-80.