Arginase inhibitor 1
Arginase inhibitor 1 is a potent inhibitor of human arginases I and II with IC50s of 223 and 509 nM, respectively.
Product Specifications
CAS Number
[1345808-25-4]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Arginase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Arginase-inhibitor-1.html
Purity
98.0
Solubility
DMSO : ≥ 48 mg/mL|H2O : ≥ 30 mg/mL
Smiles
O=C(O)[C@@](CCN1CCCCC1)(N)CCCCB(O)O
Molecular Formula
C13H27BN2O4
Molecular Weight
286.18
Precautions
H302, H315, H319, H335
References & Citations
[1]Van Zandt MC, et al. Discovery of (R) -2-amino-6-borono-2- (2- (piperidin-1-yl) ethyl) hexanoic acid and congeners as highly potentinhibitors of human arginases I and II for treatment of myocardial reperfusion injury. J Med Chem. 2013 Mar 28;56 (6) :2568-80.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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