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GET73

GET73 is a γ-hydroxybutyric acid (GHB) analog, a naturally occurring neurotransmitter. GET73 has anti-alcohol and anxiolytic properties. GET73 significantly affects glutamate transmission in the hippocampus[1][2][3].

Product Specifications

CAS Number

[202402-01-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/get73.html

Concentration

10mM

Purity

98.69

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=C(C(F)(F)F)C=C1)CCCOC

Molecular Formula

C13H16F3NO2

Molecular Weight

275.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Tomasini MC, et al. GET73 Prevents Ethanol-Induced Neurotoxicity in Primary Cultures of Rat Hippocampal Neurons. Alcohol Alcohol. 2016 Mar;51 (2) :128-35.|[2]Ferraro L, et al. GET73 modulates rat hippocampal glutamate transmission: evidence for a functional interaction with mGluR5. Pharmacol Rep. 2011;63 (6) :1359-71.|[3]Loche A, et al. Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. Front Psychiatry. 2012 Feb 14;3:8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-108034/GET73-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-108034/GET73-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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