IEM-1460
IEM-1460 blocks both AMPA and NMDA glutamate receptor with anticonvulsant effect in vivo[1].
Product Specifications
CAS Number
[121034-89-7]
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/iem-1460.html
Purity
98.0
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[N+](C)(C)CCCCCNCC12C[C@H](C3)C[C@H](C[C@H]3C2)C1.Br.[Br-]
Molecular Formula
C19H38Br2N2
Molecular Weight
454.33
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Schlesinger F, et al. Two mechanisms of action of the adamantane derivative IEM-1460 at human AMPA-type glutamate receptors. Br J Pharmacol. 2005 Jul;145 (5) :656-63.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AMPA Receptor
Available Sizes
Curated Selection
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