SN 2
Product Specifications
UNSPSC Description
SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV)[2].
Target Antigen
Dengue virus; Flavivirus; TRP Channel
Type
Reference compound
Related Pathways
Anti-infection;Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/SN-2.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4
Molecular Weight
255.35
References & Citations
[1]Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17(2):135-48.|[2]Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16696/SN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16696/SN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
823218-99-1
Available Sizes
Curated Selection
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