SN 2
SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) [2].
Product Specifications
CAS Number
[823218-99-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dengue Virus; Flavivirus; TRP Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/SN-2.html
Purity
99.93
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4
Molecular Formula
C17H21NO
Molecular Weight
255.35
Precautions
H302, H315, H319, H335
References & Citations
[1]Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17 (2) :135-48.|[2]Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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