SN 2

SN 2 is a potent activator of TRPML3 ion channel with an EC50 of 1.8 μM[1]. SN 2 also acts as a potent inhibitor of Dengue virus 2 (DENV2) and Zika virus (ZIKV) [2].

Product Specifications

CAS Number

[823218-99-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dengue Virus; Flavivirus; TRP Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/SN-2.html

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(C=C(C)C=C1C)=C1C2=NOC3C2C4CC3CC4

Molecular Formula

C17H21NO

Molecular Weight

255.35

Precautions

H302, H315, H319, H335

References & Citations

[1]Grimm C, et al. Small molecule activators of TRPML3. Chem Biol. 2010 Feb 26;17 (2) :135-48.|[2]Zhiqiang Xia, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020 Aug 26;104922.