WWL229
WWL229 is a selective inhibitor of carboxylesterase 3 (Ces3) with an IC50 of 1.94 µM. WWL229 promotes lipid storage in cultured adipocytes and prevents basal lipolysis[1].
Product Specifications
CAS Number
[1338575-28-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Carboxylesterase (CES)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/wwl229.html
Purity
99.49
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N1CCCCC1CCCOC)OC2=CC=C(C=C2)[N+]([O-])=O
Molecular Formula
C16H22N2O5
Molecular Weight
322.36
Precautions
H302, H315, H319
References & Citations
[1]Dominguez E, et al. Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes. Nat Chem Biol. 2014 Feb;10 (2) :113-21.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CES3
Available Sizes
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