PRE-084 (hydrochloride)

PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].

Product Specifications

CAS Number

[75136-54-8]

UNSPSC

12352005

Target

Akt; NO Synthase; Sigma Receptor

Type

Reference compound

Related Pathways

Immunology/Inflammation; Neuronal Signaling; PI3K/Akt/mTOR

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/PRE-084-hydrochloride.html

Purity

99.92

Solubility

DMSO : 17.5 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1(C2=CC=CC=C2)CCCCC1)OCCN3CCOCC3.[H]Cl

Molecular Formula

C19H28ClNO3

Molecular Weight

353.88

References & Citations

[1]Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16 (11) :1223-6. |[2]Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32. |[3]Gao QJ, et al. Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats. Chin Med J (Engl) . 2018 Mar 5;131 (5) :539-543. |[4]Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259 (2) :543-50.