INCB-057643
INCB-057643 is a novel, orally bioavailable BET inhibitor.
Product Specifications
CAS Number
[1820889-23-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/INCB-057643.html
Concentration
10mM
Purity
98.29
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1C(C)(C)OC2=C(C3=CN(C)C(C4=C3C=CN4)=O)C=C(S(=O)(C)=O)C=C2N1C
Molecular Formula
C20H21N3O5S
Molecular Weight
415.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Matthew C. Stubbs, et al. Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies. AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5071.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Curated Selection
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