INCB-057643

INCB-057643 is a novel, orally bioavailable BET inhibitor.

Product Specifications

CAS Number

[1820889-23-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Apoptosis; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/INCB-057643.html

Concentration

10mM

Purity

98.29

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C1C(C)(C)OC2=C(C3=CN(C)C(C4=C3C=CN4)=O)C=C(S(=O)(C)=O)C=C2N1C

Molecular Formula

C20H21N3O5S

Molecular Weight

415.46

Precautions

H302, H315, H319, H335

References & Citations

[1]Matthew C. Stubbs, et al. Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignancies. AACR; Cancer Res 2017;77 (13 Suppl) :Abstract nr 5071.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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