D-Pantothenic acid (hemicalcium salt)

D-Pantothenic acid hemicalcium salt is an orally active vitamin that reduces patulin in apple juice. D-Pantothenic acid hemicalcium salt removes ROS. D-Pantothenic acid hemicalcium salt has antibacterial and immunomodulatory activities. D-Pantothenic acid hemicalcium salt also has the effect of improving osteoporosis and obesity[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[137-08-6]

Product Name Alternative

Calcium pantothenate; Calcium D-pantothenate; Vitamin B5 calcium salt

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS)

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Endocrinology; Metabolic Disease; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/D-Pantothenic-acid-hemicalcium-salt.html

Purity

99.80

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O[C@@H](C(NCCC([O-])=O)=O)C(C)(C)CO.[0.5Ca2+]

Molecular Formula

C9H16NO5.1/2Ca

Molecular Weight

238.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Weimann BI, et al. Studies on wound healing: effects of calcium D-pantothenate on the migration, proliferation and protein synthesis of human dermal fibroblasts in culture. Int J Vitam Nutr Res. 1999 Mar;69 (2) :113-9.|[2]Serafettin Yazici, et al. Effect of thiamine hydrochloride, pyridoxine hydrochloride and calcium-d-pantothenate on the patulin content of apple juice concentrate. Food / Nahrung Volume 46, Issue 4, pages 256–257, 1 July 2002|[3]Chen C, et al. Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation. Cell Rep. 2022 Nov 29;41 (9) :111741.|[4]Zhou H, et al. Pantothenate protects against obesity via brown adipose tissue activation. Am J Physiol Endocrinol Metab. 2022 Jul 1;323 (1) :E69-E79.|[5]Ma Q, et al. Vitamin B5 inhibit RANKL induced osteoclastogenesis and ovariectomy induced osteoporosis by scavenging ROS generation. Am J Transl Res. 2019 Aug 15;11 (8) :5008-5018.|[6]He W, et al. Vitamin B5 Reduces Bacterial Growth via Regulating Innate Immunity and Adaptive Immunity in Mice Infected with Mycobacterium tuberculosis. Front Immunol. 2018 Feb 26;9:365. |[7]Wang X, et al. Vitamin B5 supplementation enhances intestinal development and alters microbes in weaned piglets. Anim Biotechnol. 2024 Nov;35 (1) :2335340. |[8]Asadi P, et al. Vitamin B5, a coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells. J Inherit Metab Dis. 2023 Mar;46 (2) :358-368.