Bepirovirsen (sodium)

Bepirovirsen (ISIS 505358) sodium is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen sodium leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins. Bepirovirsen sodium can be used for the research of chronic HBV infection. Bepirovirsen sodium binding site sequence (GCACTTCGCTTCACCTCTGC) [1][2][3].

Product Specifications

CAS Number

[2563929-84-8]

Product Name Alternative

ISIS 505358 (sodium)

UNSPSC

12352208

Target

HBV

Type

Oligonucleotides

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/bepirovirsen-sodium.html

Purity

98.44

Solubility

10 mM in H2O

Smiles

[Bepirovirsen(sodium)]

Molecular Formula

C230H290N88Na19O115P19S19

Molecular Weight

7344 (free acid)

References & Citations

[1]Yuen MF, et al. Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial. Nat Med. 2021 Oct;27 (10) :1725-1734.|[2]Yuen MF, et al. Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection. N Engl J Med. 2022 Nov 24;387 (21) :1957-1968.|[3]Han K, et al. Preclinical and Phase 1 Assessment of Antisense Oligonucleotide Bepirovirsen in Hepatitis B Virus-Transgenic Mice and Healthy Human Volunteers: Support for Clinical Dose Selection and Evaluation of Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses. Clin Pharmacol Drug Dev. 2022 Oct;11 (10) :1191-1202.