Sulindac sulfone
Sulindac sulfone is an mTORC1 pathway inhibitor and a metabolite of Sulindac. Sulindac sulfone inhibits colon cancer cell growth and induces cell cycle arrest. Sulindac sulfone is used in cancer research[1].
Product Specifications
CAS Number
[59973-80-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Metabolite; mTOR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sulindac-sulfone.html
Purity
98.10
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(O)CC(C1=C/2C=CC(F)=C1)=C(C)C2=C\C3=CC=C(S(=O)(C)=O)C=C3
Molecular Formula
C20H17FO4S
Molecular Weight
372.41
Precautions
H302, H315, H319, H335
References & Citations
[1]Aono Y, et al. Sulindac sulfone inhibits the mTORC1 pathway in colon cancer cells by directly targeting voltage-dependent anion channel 1 and 2. Biochem Biophys Res Commun. 2018 Nov 10;505 (4) :1203-1210.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Curated Selection
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