CYM50260

CYM50260 is a potent and exquisitely selective sphingosine-1-phosphate 4 receptor (S1P4-R) agonist with an EC50 of 45 nM. CYM50260 displays no activity against S1P1-R, S1P2-R, S1P3-R and S1P5-R[1].

Product Specifications

CAS Number

[1355026-60-6]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/cym50260.html

Purity

99.70

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

FCC1=CC=C(OCCOC2=CC=C(Cl)C=C2Cl)C(Cl)=N1

Molecular Formula

C14H11Cl3FNO2

Molecular Weight

350.60

References & Citations

[1]Guerrero M, et al. Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists. Bioorg Med Chem Lett. 2012 Jan 1;22 (1) :537-42.|[2]Onuma T, et al. Sphingosine 1-phosphate (S1P) suppresses the collagen-induced activation of human platelets via S1P4 receptor. Thromb Res. 2017 Aug;156:91-100.