Methdilazine (hydrochloride)

Methdilazine hydrochloride is an orally active antibiotic (histamine antagonist) . Methdilazine hydrochloride can inhibit various mycobacterium with MIC values at 5-15 μg/mL in vitro and in vivo, which can be used for the research of infectious diseases[1][2].

Product Specifications

CAS Number

[1229-35-2]

UNSPSC

12352005

Hazard Statement

H301

Target

Antibiotic; Bacterial; Histamine Receptor

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/methdilazine-hydrochloride.html

Purity

99.90

Solubility

DMSO : ≥ 50 mg/mL

Smiles

CN(CC1)CC1CN2C3=C(C=CC=C3)SC4=C2C=CC=C4.Cl

Molecular Formula

C18H21ClN2S

Molecular Weight

332.89

Precautions

H301

References & Citations

[1]A N Chakrabarty, et al. Antimycobacterial activity of methdilazine (Md), an antimicrobic phenothiazine. APMIS. 1993 Jun;101 (6) :449-54. |[2]Noton K Dutta, et al. Activity of the phenothiazine methdilazine alone or in combination with isoniazid or streptomycin against Mycobacterium tuberculosis in mice. J Med Microbiol. 2009 Dec;58 (Pt 12) :1667-1668.