RS-127445
RS-127445 is a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist with a pKi of 9.5. RS-127445 shows 1000 fold selectivity for this receptor as compared to numerous other receptor and ion channel binding sites[1].
Product Specifications
CAS Number
[199864-87-4]
UNSPSC
12352005
Hazard Statement
H317, H319
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rs-127445-1.html
Purity
99.95
Solubility
DMSO : ≥ 100 mg/mL
Smiles
NC1=NC(C(C)C)=CC(C2=C3C=CC=CC3=C(F)C=C2)=N1
Molecular Formula
C17H16FN3
Molecular Weight
281.33
Precautions
H317, H319
References & Citations
[1]Bonhaus DW, et al. RS-127445: a selective, high affinity, orally bioavailable 5-HT2B receptor antagonist. Br J Pharmacol. 1999 Jul;127 (5) :1075-82.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT2 Receptor; α-1 microglobulin
Available Sizes
Curated Selection
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