BAY 87-2243

BAY 87-2243 is a highly potent and selective hypoxia-inducible factor-1 (HIF-1) inhibitor.

Product Specifications

CAS Number

[1227158-85-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Ferroptosis; HIF/HIF Prolyl-Hydroxylase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BAY-87-2243.html

Purity

99.40

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCN(C6CC6)CC5)=NC=C4)C(C)=C3)=N2)C=C1

Molecular Formula

C26H26F3N7O2

Molecular Weight

525.53

Precautions

H302, H315, H319, H335

References & Citations

[1]Ellinghaus P, et al. BAY 87-2243, a highly potent and selective inhibitor of hypoxia-induced gene activation has antitumor activities by inhibition of mitochondrial complex I. Cancer Med. 2013 Oct;2 (5) :611-24.|[2]Helbig L, et al. BAY 87-2243, a novel inhibitor of hypoxia-induced gene activation, improves local tumor control after fractionated irradiation in a schedule-dependent manner in head and neck human xenografts. Radiat Oncol. 2014 Sep 19;9:207.