Amino-PEG3-2G degrader-1
Amino-PEG3-2G degrader-1 (compound) is a conjugate of a PEG Linker and a pyrazole-linked FBnG tag for ubiquitin-proteasome system (UPS) induction. Amino-PEG3-2G degrader-1 can be used to synthesize autophagy-targeting chimeras (AUTACs) [1].
Product Specifications
CAS Number
2267315-06-8
UNSPSC
12352005
Target
AUTACs; Autophagy
Type
Reference compound
Related Pathways
Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/amino-peg3-2g-degrader-1.html
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C1N=C(NC2=C1N=C(N2CC3=CC=C(C=C3)F)C4=CN(CCCOCCOCCOCCCN)N=C4)N
Molecular Formula
C25H33FN8O4
Molecular Weight
528.58
References & Citations
[1]Takahashi D, et al. Second-Generation AUTACs for Targeted Autophagic Degradation. J Med Chem. 2023 Sep 14;66 (17) :12342-12372.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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