HDAC9-IN-1

HDAC9-IN-1 (Compound 7g) is a potent HDAC9 inhibitor, with an IC50 of 40 nM. HDAC9-IN-1 significantly inhibits several human cancer cells, induces apoptosis, modulates caspase-related proteins as well as p38, and causes DNA damage[1].

Product Specifications

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hdac9-in-1.html

Purity

95.13

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

N/C(C1=CC2=C(SC3=CC=CC=C3N2CC4=CC=C(C(C5=CC=CC=C5)=C4)C(NO)=O)C=C1)=N\O

Molecular Formula

C27H22N4O3S

Molecular Weight

482.55

References & Citations

[1]Hsu KC, et al. Synthesis and biological evaluation of ortho-phenyl phenylhydroxamic acids containing phenothiazine with improved selectivity for class IIa histone deacetylases. J Enzyme Inhib Med Chem. 2024 Dec;39 (1) :2406025.