Orotic acid (Standard)

Orotic acid (Standard) is the analytical standard of Orotic acid. This product is intended for research and analytical applications. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[1][2][3].

Product Specifications

CAS Number

[65-86-1]

Product Name Alternative

6-Carboxyuracil (Standard) ; Vitamin B13 (Standard)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Nucleoside Antimetabolite/Analog; Reference Standards

Type

Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/orotic-acid-standard.html

Purity

99.51

Smiles

O=C(C(NC1=O)=CC(N1)=O)O

Molecular Formula

C5H4N2O4

Molecular Weight

156.10

Precautions

H302, H315, H319, H335

References & Citations

[1]Löffler M, et, al. Orotate (orotic acid) : An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.|[2]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15.|[3]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr;110 (4) :816-21.