2,6-Dichloro-N- (2- (cyclopropanecarboxamido) pyridin-4-yl) benzamide

GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4.8, 0.7, 0.7, and 0.4 nM for TYK2, JAK1, JAK2, and JAK3, respectively[1].

Product Specifications

CAS Number

[1258292-64-6]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

JAK

Type

Reference compound

Related Pathways

Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gdc-046.html

Purity

99.80

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC(NC(C2CC2)=O)=NC=C1)C3=C(Cl)C=CC=C3Cl

Molecular Formula

C16H13Cl2N3O2

Molecular Weight

350.20

Precautions

H302, H315, H319, H335

References & Citations

[1]Jun Liang, et al. Lead Optimization of a 4-aminopyridine Benzamide Scaffold to Identify Potent, Selective, and Orally Bioavailable TYK2 Inhibitors. J Med Chem. 2013 Jun 13;56 (11) :4521-36.