NLRP3 agonist 1

NLRP3 agonist 1 (Compound 23) is an orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms[1].

Product Specifications

CAS Number

[2454019-69-1]

UNSPSC

12352005

Target

Caspase; NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nlrp3-agonist-1.html

Purity

99.47

Solubility

DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

Smiles

NC1=NC(NC2(C)CC2)=C3C(C=C(C=C3)C4=NNC=C4)=N1

Molecular Formula

C15H16N6

Molecular Weight

280.33

References & Citations

[1]O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.