NLRP3 agonist 1
Product Specifications
UNSPSC Description
NLRP3 agonist 1 (compound 23) is a potent and orally active NLRP3 agonist. NLRP3 agonist 1 can activate the enzyme Caspase-1 to cleave pro-IL-1β and pro-IL-18 proinflammatory cytokines into their mature forms[1].
Target Antigen
NOD-like Receptor (NLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nlrp3-agonist-1.html
Solubility
DMSO : 100 mg/mL (ultrasonic;warming;heat to 80°C)
Smiles
NC1=NC(NC2(C)CC2)=C3C(C=C(C=C3)C4=NNC=C4)=N1
Molecular Weight
280.33
References & Citations
[1]O' Donovan DH, et, al. Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice. Bioorg Med Chem Lett. 2023 Oct 12:96:129518.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-156413/NLRP3-agonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-156413/NLRP3-agonist-1-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2454019-69-1
Available Sizes
Curated Selection
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