Methylnissolin
Methylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet-derived growth factor (PDGF) -BB-induced cell proliferation with an IC50 of 10 μM. Methylnissolin inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinase. Methylnissolin inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibition of the ERK1/2 MAP kinase cascade[1].
Product Specifications
CAS Number
[73340-41-7]
Product Name Alternative
Astrapterocarpan
UNSPSC
12352005
Hazard Statement
H315, H319
Target
ERK; PDGFR
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/methylnissolin.html
Purity
99.92
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
COC1=C2O[C@]3([H])[C@](COC4=CC(O)=CC=C34)([H])C2=CC=C1OC
Molecular Formula
C17H16O5
Molecular Weight
300.31
Precautions
H315, H319
References & Citations
Astragalus membranaceus
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ERK1; ERK2; PDGFR
Available Sizes
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