Human α-defensin 5

Human α-defensin 5 is an antiviral peptide. Human α-defensin 5 blocks infection of non-enveloped viruses, including AdV, HPV, and polyomaviruses (IC50: 0.6-1.25 μM for HPV16) . Human α-defensin 5 can bind to the viral capsid and blocks escape of the virus from the endosome. Human α-defensin 5 increases HIV binding to the cell surface. Human α-defensin 5 also has parasiticidal activity[1].

Product Specifications

UNSPSC

12352209

Target

HPV; Parasite

Type

Peptides

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/human-α-defensin-5.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](N)C)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H]1C(C)C)=O)=O)CO)=O)CC(C)C)=O)CO)=O)CCC(O)=O)=O)CCCNC(N)=N)=O)[C@@H](C)O)=O)C)=O)CSSC[C@@H]2NC3=O)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O)=O)CCCNC(N)=N)=O)CSSC[C@H](NC1=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC(C)C)=O)CCCNC(N)=N)=O)CC4=CC=C(O)C=C4)=O)CC(C)C)=O)CCCNC(N)=N)=O)=O)CO)=O)[C@H](CC)C)=O)CCC(O)=O)=O)=O)CC5=CC=C(O)C=C5)=O)CSSC[C@H](NC2=O)C(N[C@H](C(O)=O)CCCNC(N)=N)=O)=O)[C@@H](C)O

Molecular Formula

C144H238N50O45S6

Molecular Weight

3582.13

References & Citations

[1]Gounder AP, et al. Critical determinants of human α-defensin 5 activity against non-enveloped viruses. J Biol Chem. 2012 Jul 13;287 (29) :24554-62.|[2]Tanaka T, et al. Parasiticidal activity of human alpha-defensin-5 against Toxoplasma gondii. In Vitro Cell Dev Biol Anim. 2010 Jun;46 (6) :560-5.