MNI137

MNI137 is a potent and selective negative allosteric modulator for group II mGluRs. MNI137 has IC50s values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization[1].

Product Specifications

CAS Number

[946619-21-2]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mni137.html

Purity

95.0

Solubility

DMSO : 83.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

N#CC1=NC=CC(C2=NC3=CC=C(Br)C=C3NC(C2)=O)=C1

Molecular Formula

C15H9BrN4O

Molecular Weight

341.16

References & Citations

[1]Hemstapat K, et al. A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J Pharmacol Exp Ther. 2007;322 (1) :254-264.