DMBA-SIL-Mal-MMAE
DMBA-SIL-Mal-MMAE is a cytotoxin-linker conjugate for ADC with potent antitumor activity by using the anti-mitotic agent, monomethyl auristatin E (MMAE, a tubulin inhibitor), linked DMBA-SIL-Mal[1].
Product Specifications
CAS Number
[2923885-49-6]
UNSPSC
12352203
Target
Drug-Linker Conjugates for ADC
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dmba-sil-mal-mmae.html
Purity
99.79
Solubility
10 mM in DMSO
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC(OCC4=CC(OC)=CC(OC)=C4)=O)C(NCCOCCOCCOCCOCCN5C(C=CC5=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C72H106N8O20
Molecular Weight
1403.65
References & Citations
[1]Jeremy M Quintana, et al. Radiation Cleaved Drug-Conjugate Linkers Enable Local Payload Release. Bioconjug Chem. 2022 Aug 17;33 (8) :1474-1484.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
GTR15175899 1 Vial
Lentiviral mouse Rpp21 shRNA (UAS) - Lentiviral mouse Rpp21 shRNA (UAS, iRFP) (100)
Ask
View Details 
NBP2-90349MFV450 0.1 mL
Rabbit Monoclonal Carbonic Anhydrase XIV/CA14 Antibody (033) [mFluor Violet 450 SE]
Ask
View Details