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Nilotinib (monohydrochloride monohydrate)

Nilotinib monohydrochloride monohydrate is a second generation tyrosine kinase inhibitor (TKI), is significantly potent against BCR-ABL, and is active against many BCR-ABL mutants.

Product Specifications

CAS Number

[923288-90-8]

Product Name Alternative

AMN107 (monohydrochloride monohydrate)

UNSPSC

12352005

Hazard Statement

H315, H317, H318, H334, H335, H341, H361, H370, H413

Target

Autophagy; Bcr-Abl

Type

Reference compound

Related Pathways

Autophagy; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Nilotinib-monohydrochloride-monohydrate.html

Purity

99.97

Solubility

DMSO : 33.33 mg/mL (ultrasonic) |H2O : 12.9 mg/mL (ultrasonic; warming; adjust pH to 1 with 1 M HCl; heat to 60°C)

Smiles

O=C(NC1=CC(C(F)(F)F)=CC(N2C=NC(C)=C2)=C1)C3=CC=C(C)C(NC4=NC=CC(C5=CC=CN=C5)=N4)=C3.[H]Cl.O

Molecular Formula

C28H25ClF3N7O2

Molecular Weight

583.99

Precautions

H315, H317, H318, H334, H335, H341, H361, H370, H413

References & Citations

[1]Weisberg E, et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. Blood. 2007 Mar 1;109 (5) :2112-20.|[2]Sako H, et al. Antitumor effect of the tyrosine kinase inhibitor Nilotinib on gastrointestinal stromal tumor (GIST) and Imatinib-resistant GIST cells. PLoS One. 2014 Sep 15;9 (9) :e107613.|[3]Dervis Hakim G, et al. Mucosal healing effect of nilotinib in indomethacin-induced enterocolitis: A rat model. World J Gastroenterol. 2015 Nov 28;21 (44) :12576-85.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

BioRxiv. January 25, 2022.|Cell Rep Methods. 2023 Oct 23;3 (10) :100599.|Drug Metab Pharmacokinet. 2020 Feb;35 (1) :102-110.|ACS Chem Biol. 2016 Apr 15;11 (4) :992-1000.|Biomaterials. 2022 Oct:289:121800.|Biomed Chromatogr. 2019 Dec;33 (12) :e4674.|Biomed Pharmacother. 2025 Jun 20:189:118246.|Biomolecules. 2022 Jun 11;12 (6) :819.|bioRxiv. 2024 Dec 20:2024.12.19.629301.|bioRxiv. 2024 Dec 22:2024.12.21.629902.|bioRxiv. 2024 May 8:2024.05.07.592424.|bioRxiv. 2025 February 26.|bioRxiv. 2025 Sep 30.|Blood Vessel Thromb Hemost. 2025 Nov 17.|Br J Cancer. 2022 Mar;126 (5) :778-790.|Breast Cancer Res. 2023 May 5;25 (1) :51.|Cancer Biol Ther. 2019;20 (6) :877-885.|Cancer Lett. 2024 Aug 1:217150.|Cancer Med. 2016 Nov;5 (11) :3223-3234.|Cancer Res. 2025 Jan 2;85 (1) :101-117.|Cell Death Dis. 2021 Sep 25;12 (10) :875.|Cell Mol Immunol. 2024 Aug;21 (8) :856-872.|Cell Rep Med. 2025 Apr 2:102053.|Cell Syst. 2018 Apr 25;6 (4) :424-443.e7.|Diseases. 2023 Oct 23;11 (4) :147.|Ecotoxicol Environ Saf. 2025 Nov 15:307:119433.|Eur J Pharmacol. 2021 Apr 15:897:173944.|Glia. 2022 Jun;70 (6) :1084-1099.|Harvard Medical School LINCS LIBRARY|Int J Mass Spectrom. 442 (2019) 44-50.|J Pharm Sci. 2017 Sep;106 (9) :2632-2641.|Leuk Lymphoma. 2015;56 (8) :2416-23. |Mol Med Rep. 2025 Jun;31 (6) :165.|Oncotarget. 2018 Apr 24;9 (31) :22158-22183. |Patent. US20190084960A1|Patent. US20210299273A1.|Phytomedicine. 2025 Sep 25:148:157332.|PLoS One. 2024 Nov 1;19 (11) :e0308647.|Research Square Preprint. 2024 Nov 06.|Sci Transl Med. 2018 Jul 18;10 (450) :eaaq1093.|Stem Cell Reports. 2019 May 14;12 (5) :996-1006. |Target Oncol. 2020 Oct;15 (5) :659-671.|Technical University of Munich. 24.01.2018.|Toxicol Lett. 2022 Jul 15:365:11-23.|Toxicology. 2024 May 15:505:153830.|Xenobiotica. 2018 Oct;48 (10) :1059-1071.

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