TGR5 agonist 7
TGR5 agonist 7 (Compound 22-Na) is a gut-restricted, orally active agonist for G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 [1].
Product Specifications
UNSPSC
12352211
Target
G protein-coupled Bile Acid Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/tgr5-agonist-7.html
Smiles
O=C([C@]1(CC[C@@]2([H])[C@](C)([H])COC(NCCS(=O)(O[Na])=O)=O)[C@@]2([H])[C@@]3([H])CC[C@]4([H])[C@@]5(C)CC[C@@H](OC(NC6CC6)=O)C(C)(C)[C@]5([H])CC[C@@]4(C)[C@]3(C)CC1)O
Molecular Formula
C37H59N2NaO9S
Molecular Weight
730.93
References & Citations
[1]Zhuo N, et al., Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties. Bioorg Chem. 2024 Mar;144:107132.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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