Icilin

Icilin (AG-3-5) is a super-agonist of the transient receptor potential M8 (TRPM8) ion channel. Icilin activates TRPM8 in EGTA in a dose-dependent manner (EC50=1.4 μM) . Icilin is a "super-cooling agent" [1][2]. Icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response[3].

Product Specifications

CAS Number

[36945-98-9]

Product Name Alternative

AG-3-5

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-Kinase/protease

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Icilin.html

Concentration

10mM

Purity

99.26

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC=CC=C2O)CC=C(C3=CC=CC([N+]([O-])=O)=C3)N1

Molecular Formula

C16H13N3O4

Molecular Weight

311.29

Precautions

H302, H312, H332

References & Citations

[1]Huai-hu Chuang, et al. The super-cooling agent icilin reveals a mechanism of coincidence detection by a temperature-sensitive TRP channel. Neuron. 2004 Sep 16;43 (6) :859-69.|[2]Viktor V Feketa, et al. Transient receptor potential melastatin 8 channel inhibition potentiates the hypothermic response to transient receptor potential vanilloid 1 activation in the conscious mouse. Crit Care Med. 2014 May;42 (5) :e355-63.|[3]Benjamin W Ewanchuk, et al. The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response. FASEB J. 2018 Mar;32 (3) :1236-1249.