PC Azido-PEG11-NHS carbonate ester

PC Azido-PEG11-NHS carbonate ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PC Azido-PEG11-NHS carbonate ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

UNSPSC

12352005

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pc-azido-peg11-nhs-carbonate-ester.html

Purity

90.42

Solubility

10 mM in DMSO

Smiles

O=C(CCCOC1=CC([N+]([O-])=O)=C(C(C)OC(ON2C(CCC2=O)=O)=O)C=C1OC)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C42H68N6O21

Molecular Weight

993.02

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562