TNNC1 rabbit pAb
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008],
Product Specifications
Background
UniProt
P63316
Swiss Prot
P63316
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human TNNC1 AA range: 57-107
Target
TNNC1
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleoplasm, mitochondrion, cytosol, troponin complex, actin cytoskeleton, contractile fiber
Gene ID (Human)
7134
Available Sizes
Frequently Asked Questions
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