(Rac) -Ketoconazole

(Rac) -Ketoconazole ((Rac) -R 41400) is an antifungal imidazole compound with oral activity. (Rac) -Ketoconazole interferes with ergosterol synthesis by inhibiting cytochrome P450-dependent 14α-sterol demethylase (CYP51), a key enzyme on the fungal cell membrane, leading to membrane dysfunction and ultimately inhibition of fungal growth and reproduction. (Rac) -Ketoconazole is indicated for studies of fungal infections[1].

Product Specifications

CAS Number

[79156-75-5]

Product Name Alternative

(Rac) -Ketoconazol; (Rac) -R 41400

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Cytochrome P450; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/rac-ketoconazole.html

Smiles

CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Molecular Formula

C26H28Cl2N4O4

Molecular Weight

531.43

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Chenge J T, et al. Structural characterization and ligand/inhibitor identification provide functional insights into the Mycobacterium tuberculosis cytochrome P450 CYP126A1[J]. Journal of Biological Chemistry, 2017, 292 (4) : 1310-1329.