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SRI-011381

SRI-011381 is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2].

Product Specifications

CAS Number

[1629138-41-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TGF-beta/Smad

Type

Reference compound

Related Pathways

Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sri-011381.html

Purity

99.84

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3

Molecular Formula

C20H31N3O

Molecular Weight

329.48

Precautions

H302, H315, H319, H335

References & Citations

[1]Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3) /Transforming Growth Factor-β1 (TGF-β1) /α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978.|[2]Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11 (17) :8480-8499.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Am J Physiol Cell Physiol. 2025 Jul 1;329 (1) :C170-C182.|Biochem Genet. 2025 Jul 1.|Biochim Biophys Acta Mol Basis Dis. 2025 Jan 28:167696.|Biomed Pharmacother. 2025 May 1:187:118094.|Br Food J. 2025 Jun 11;127 (8) :2759–2776.|Cell Immunol. 2024 Jan-Feb:395-396:104781.|Cell Prolif. 2025 Mar;58 (3) :e13765.|Dis Markers. 2022 May 7;2022:9230647.|Discov Med. 2025 Jun 30.|Front Biosci (Landmark Ed) . 2025 Oct 29;30 (10) :45595.|Int J Mol Sci. 2024 Nov 2;25 (21) :11778.|Int J Mol Sci. 2025 Jan 4;26 (1) :395.|Int J Pharm X. 2024 Dec.|J Agric Food Chem. 2022 Sep 7;70 (35) :10782-10793.|J Cell Mol Med. 2024 Nov;28 (21) :e70199.|J Ethnopharmacol. 2024 Oct 1;337 (Pt 2) :118876.|Oncol Lett. 2024 Mar 26;27 (5) :227.|Pathol Res Pract. 2025 Mar 23:269:155899.|Phytother Res. 2023 May;37 (5) :1771-1786.|Sci China Life Sci. 2025 Mar;68 (3) :746-763.|Biomed Res Int. 2020 Nov 16;2020:8039840.|Biosci Rep. 2020 Nov 27;40 (11) :BSR20201545.|Cancer Cell Int. 2022 May 16;22 (1) :191.|Cell Commun Signal. 2023 Jul 4;21 (1) :168.|Cell Cycle. 2021 Feb;20 (3) :256-270.|Cell Mol Biol Lett. 2023 Feb 27;28 (1) :15.|Chem Res Toxicol. 2022 Feb 21;35 (2) :233-243.|Curr Med Sci. 2019 Aug;39 (4) :534-540.|Dev Comp Immunol. 2018 Nov:88:144-151.|Drug Dev Res. 2019 Nov;80 (7) :992-999.|Eur J Pharmacol. 2021 Oct 5;908:174356.|Evid Based Complement Alternat Med. 2023 Jan 12:2023:6018375.|Exp Eye Res. 2019 May:182:44-56.|Free Radic Biol Med. 2025 Apr:231:178-192.|Int J Med Sci. 2025 Mar 31;22 (9) :2031-2039.|J Cardiothorac Surg. 2024 May 10;19 (1) :283.|J Cell Mol Med. 2021 Apr;25 (7) :3272-3283.|J Ethnopharmacol. 2024 Mar 25:322:117507.|Laryngoscope. 2024 Sep;134 (9) :4078-4087.|Life Sci. 2021 Aug 15;279:119359.|Mol Cell Biochem. 2019 Jun;456 (1-2) :95-104. |Mol Med Rep. 2021 Nov;24 (5) :758.|Nature. 2023 Jan;613 (7942) :120-129.|Neurobiol Dis. 2024 Jun 18:199:106573.|Oncol Lett. 2024 May 30;28 (2) :346.|Phytomedicine. 2022 Aug:103:154234.|Phytomedicine. 2022 Mar 21;100:154067.|Reprod Domest Anim. 2023 Feb;58 (2) :323-332.|Research Square Preprint. 2020 Dec.|Sci Rep. 2024 Oct 15;14 (1) :24091.|Stem Cells. 2024 May 8:sxae032.|Theranostics. 2021; 11 (17) :8480-8499.

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