ARD-1676

ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].

Product Specifications

CAS Number

[2632305-36-1]

UNSPSC

12352005

Target

Androgen Receptor; PROTACs

Type

Reference compound

Related Pathways

PROTAC; Vitamin D Related/Nuclear Receptor

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ard-1676.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

C[C@H]1CC2(CN1C3=CC=C(C(Cl)=C3)C#N)CCN(CC2)C4=CC=C(C=C4)C(N5CCC(CC5)CN6CC7=C(C6)C=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O)=O

Molecular Formula

C44H46ClN7O5

Molecular Weight

788.33

References & Citations

[1]Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 8..