What is the catalog number for Ivacaftor?

The catalog number for Ivacaftor is HY-13017.

What sizes are available for Ivacaftor?

Ivacaftor is available in the following size(s): 5 mg, 10 mM - 1 mL, 10 mg, 25 mg, 50 mg, 100 mg.

How many pack sizes does Ivacaftor come in?

Ivacaftor is available in 6 different pack sizes.

Is Ivacaftor in stock?

Ivacaftor is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Ivacaftor?

Ivacaftor is manufactured by QuantiMol.

What is the estimated delivery time for Ivacaftor?

Estimated delivery time for Ivacaftor is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Ivacaftor?

The safety data sheet for Ivacaftor is available here: http://file.medchemexpress.com/batch_PDF/HY-13017/Ivacaftor-SDS-MedChemExpress.pdf.

Ivacaftor

Ivacaftor (VX-770) is a potent and orally bioavailable CFTR potentiator, targeting G551D-CFTR and F508del-CFTR with EC50s of 100 nM and 25 nM, respectively.

Product Specifications

CAS Number

873054-44-5

Product Name Alternative

VX-770

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; CFTR

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/Ivacaftor.html

Purity

99.97

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC(C)(C1=C(C=C(C(C(C)(C)C)=C1)O)NC(C2=CNC3=C(C2=O)C=CC=C3)=O)C

Molecular Formula

C24H28N2O3

Molecular Weight

392.49

Precautions

H302, H315, H319, H335

References & Citations

[1]Delaunay JL, et al. Functional defect of variants in the adenosine triphosphate-binding sites of ABCB4 and their rescue by the cystic fibrosis transmembrane conductance regulator potentiator, ivacaftor (VX-770) . Hepatology. 2017 Feb;65 (2) :560-570|[2]Mutyam V, et al. Therapeutic benefit observed with the CFTR potentiator, ivacaftor, in a CF patient homozygous for the W1282X CFTR nonsense mutation. J Cyst Fibros. 2017 Jan;16 (1) :24-29|[3]Hadida S, et al. Discovery of N- (2,4-di-tert-butyl-5-hydroxyphenyl) -4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. J Med Chem. 2014 Dec 11;57 (23) :9776-9|[4]Van Goor F, et al. Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770. Proc Natl Acad Sci U S A. 2009 Nov 3;106 (44) :18825-30.