Topoisomerase II inhibitor 20
Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC50 of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Topoisomerase
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/topoisomerase-ii-inhibitor-20.html
Purity
98.44
Solubility
DMSO : 4 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CN(CC)C2=C(C=C(F)C(N3CC(C)NCC3)=C2F)C1=O)N/N=C/C4=CC=CS4
Molecular Formula
C22H23F2N5O2S
Molecular Weight
459.51
References & Citations
[1]Adly ME, et al. Design, synthesis and in vitro anticancer activity of some new lomefloxacin derivatives. Sci Rep. 2024 Mar 14;14 (1) :6175
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II
Available Sizes
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