9-β-D-Arabinofuranosylguanine

9-β-D-Arabinofuranosylguanine is a Guanosine (HY-N0097) analog and shows high affinity for deoxyguanosine kinase (dGK) with a Km of 8.0 μM. 9-β-D-Arabinofuranosylguanine can be used for the research of T-cell lymphoblastic disease[1][2].

Product Specifications

CAS Number

[38819-10-2]

Product Name Alternative

AraG

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/9-β-d-arabinofuranosylguanine.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1C2=C(N=C(N)N1)N([C@H]3[C@@H](O)[C@H](O)[C@@H](CO)O3)C=N2

Molecular Formula

C10H13N5O5

Molecular Weight

283.24

Precautions

H302, H315, H319, H335

References & Citations

[1]Shewach DS, et al. Differential metabolism of 9-beta-D-arabinofuranosylguanine in human leukemic cells. Cancer Res. 1989 Dec 1;49 (23) :6498-502.|[2]Lotfi K, et al. Low level of mitochondrial deoxyguanosine kinase is the dominant factor in acquired resistance to 9-beta-D-arabinofuranosylguanine cytotoxicity. Biochem Biophys Res Commun. 2002 May 24;293 (5) :1489-96.