PARP7-IN-17
PARP7-IN-17 is a potent inhibitor of PARP7 with IC50 of 4.5 nM that has oral bioavailability. PARP7-IN-17 displays antitumor effect[1].
Product Specifications
CAS Number
[3024030-10-9]
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp7-in-17.html
Purity
99.81
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CC2=CN(N=C21)[C@@H](C)C(N3CCN(CC3)C4=NC=C(C=N4)C(F)(F)F)=O)N
Molecular Formula
C20H20F3N7O2
Molecular Weight
447.41
References & Citations
[1]Hongfeng Gu, et al. Discovery of Highly Selective PARP7 Inhibitors with a Novel Scaffold for Cancer Immunotherapy. J Med Chem. 2023 Dec 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP7
Available Sizes
Curated Selection
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