Rafutrombopag (tautomerism)
Rafutrombopag (tautomerism) (Hetrombopag) is an orally active nonpeptide thrombopoietin receptor (TPOR/MPL) agonist. Rafutrombopag can chelate iron and alleviate iron overload while promoting haematopoiesis. Rafutrombopag specifically stimulates proliferation and differentiation of human TPOR‐expressing cells, including 32D‐ MPL and human hematopoietic stem cells through stimulation of STAT, PI3K and ERK signalling pathways. Rafutrombopag effectively up-regulates G1-phase-related proteins, including p-RB, Cyclin D1 and CDK4/6, normalizes progression of the cell cycle, and prevents apoptosis by modulating BCL-XL/BAK expression in 32D-MPL cells. Rafutrombopag protects cardiomyocyte survival from oxidative stress damage as an enhancer of stem cells. Rafutrombopag can be used for the study of immune thrombocytopenia and oxidative stress-related cardiovascular disease[1][2][3].
Product Specifications
CAS Number
2114365-78-3
Product Name Alternative
Hetrombopag (tautomerism) ; SHR-8735 (tautomerism)
UNSPSC
12352005
Target
Apoptosis; CDK; ERK; PI3K; STAT; Thrombopoietin Receptor
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/hetrombopag.html
Purity
98.33
Solubility
DMF : 6.25 mg/mL (ultrasonic; warming; heat to 60°C) |DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C2=C(O)C(/N=N/C3C(N(C4=CC=C5C(CCCC5)=C4)N=C3C)=O)=CC=C2)O1)O
Molecular Formula
C25H22N4O5
Molecular Weight
458.47
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
CDK4; CDK6; PI3K
Available Sizes
Frequently Asked Questions
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