BMS-684

BMS-684 is a selective DGKα inhibitor with an IC50 of 15 nM. BMS-684 inhibits DGKα kinase activity with >100-fold selectivity over the related DGK type I family members DGKβ and DGKγ. BMS-684 does not inhibit any of the other seven DGK isozymes[1].

Product Specifications

CAS Number

[313552-29-3]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

DGK

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bms-684.html

Purity

99.76

Solubility

DMSO : 14.29 mg/mL (ultrasonic; warming)

Smiles

CN(C1=CC=CC=C1C(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=C5[N+]([O-])=O)C5=O

Molecular Formula

C27H26N4O3

Molecular Weight

454.52

Precautions

H315, H319, H335

References & Citations

[1]Michael Wichroski, et al. DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Sci Transl Med. 2023 Oct 25;15 (719) :eadh1892.