GLP-1R Antagonist 1

GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM[1].

Product Specifications

CAS Number

[488097-06-9]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GCGR

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/glp-1r-antagonist-1.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC(C3=CC=C(Cl)C=C3)=NC2(C(F)(F)F)C(F)(F)F)N(C)C(N1C)=O

Molecular Formula

C16H11ClF6N4O2

Molecular Weight

440.73

Precautions

H302, H315, H319, H335

References & Citations

[1]Kellie D. Nance, et al. Discovery of a novel series of orally bioavailable and CNS penetrant Glucagon-Like Peptide 1 Receptor (GLP-1R) non-competitive antagonists based on a 1,3-disubstituted-7-aryl-5,5-bis (trifluoromethyl) -5,8-dihydropyrimido[4,5-d]pyrimidine-2,4 (1H,3H) -dione core. J. Med. Chem. 19 Jan 2017.