Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SBI-797812

SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD+ in mice[1][2].

Product Specifications

CAS Number

2237268-08-3

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

NAMPT

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sbi-797812.html

Purity

99.88

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(NCC1=CC=NC=C1)NC2=CC=C(S(=O)(N3CC(O4)CCC4C3)=O)C=C2

Molecular Formula

C19H22N4O4S

Molecular Weight

402.47

Precautions

H302, H315, H319

References & Citations

[1]Gardell SJ , et al. Boosting NAD+ with a small molecule that activates NAMPT. Nat Commun. 2019 Jul 19;10 (1) :3241.|[2]Khaidizar FD, et al. Nicotinamide Phosphoribosyltransferase as a Key Molecule of the Aging/Senescence Process. Int J Mol Sci. 2021 Apr 2;22 (7) :3709.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) (rKRT16/1714), CF405S conjugate, 0.1mg/mL
BNC042149-500 1x 500 µL

Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker) (rKRT16/1714), CF405S conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Tissue FFPE Sections, Thyroid gland
CS800854 5x 5 µm

Tissue FFPE Sections, Thyroid gland

Sign In for Pricing
View Details
MEAK7 (TLDC1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3C4]
TA501008AM 100 µL

MEAK7 (TLDC1) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI3C4]

Sign In for Pricing
View Details
NLRX1 (NM_024618) Human Recombinant Protein
TP761922 50 µg

NLRX1 (NM_024618) Human Recombinant Protein

Sign In for Pricing
View Details
Isopar G
TRC-I821835-1L 1 L

Isopar G

Sign In for Pricing
View Details
1-(2,3-Dihydro-1H-indol-1-yl)prop-2-en-1-one
TRC-D453013-50MG 50 mg

1-(2,3-Dihydro-1H-indol-1-yl)prop-2-en-1-one

Sign In for Pricing
View Details