ASK1-IN-2
Product Specifications
UNSPSC Description
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].
Target Antigen
Apoptosis; MAP3K
Type
Reference compound
Related Pathways
Apoptosis;MAPK/ERK Pathway
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ask1-in-2.html
Purity
99.55
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C(N1)=CC2=C1C=C(F)C=C2)NC3=NC(C4=NN=CN4C(C)C)=CC=C3
Molecular Weight
364.38
References & Citations
[1]Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131969/ASK1-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131969/ASK1-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2541792-70-3
Available Sizes
Curated Selection
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