ASK1-IN-2

ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].

Product Specifications

CAS Number

[2541792-70-3]

UNSPSC

12352005

Target

Apoptosis; ASK1; MAP3K

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ask1-in-2.html

Concentration

10mM

Purity

99.55

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(C(N1)=CC2=C1C=C(F)C=C2)NC3=NC(C4=NN=CN4C(C)C)=CC=C3

Molecular Formula

C19H17FN6O

Molecular Weight

364.38

References & Citations

[1]Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.