ASK1-IN-2
ASK1-IN-2 is a potent and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1), with an IC50 of 32.8 nM. ASK1-IN-2 can be used for the research of ulcerative colitis[1].
Product Specifications
CAS Number
2541792-70-3
UNSPSC
12352005
Target
Apoptosis; ASK1; MAP3K
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ask1-in-2.html
Concentration
10mM
Purity
99.55
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C(N1)=CC2=C1C=C(F)C=C2)NC3=NC(C4=NN=CN4C(C)C)=CC=C3
Molecular Formula
C19H17FN6O
Molecular Weight
364.38
References & Citations
[1]Hou S, et, al. Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis. Eur J Med Chem. 2020 Dec 24;211:113114.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAP3K5/ASK1
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
VAng-Lsx8911-500gEcoli 500 µg (E. coli)
Recombinant Clostridium Cellulolyticum cobT Protein (aa 1-352)
Sign In for Pricing
View Details 
bsm-62891R-BF488-TR 20 µL
Phospho-LRRK2 (Ser935) Recombinant Antibody, AbBy Fluor™ 488 Conjugated
Sign In for Pricing
View Details RR203080L4V 200 µL
Taar1 (NM_134328) Rat Tagged ORF Clone Lentiviral Particle
Sign In for Pricing
View Details